[Pubmed] Mitochondrial autophagy-related gene signatures associated with myasthenia gravis diagnosis and immunity

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Autoimmunity. 2025 Dec;58(1):2465410. doi: 10.1080/08916934.2025.2465410. Epub 2025 Feb 12.

ABSTRACT

Myasthenia gravis (MG) is a common autoimmune disorder that causes skeletal muscle weakness. Most patients presented with skeletal muscle weakness and endurance decline. Mitophagy refers to removing and interpreting aging or damaged mitochondria in cells. This plays a vital role in maintaining cell homeostasis and normal function. This study explores the role of mitophagy-related genes (GM) in MG. Specifically, we collected the transcriptome data of MG and its control group from the GEO database (Gene Expression Omnibus database). The differentially expressed genes (DEGs) were identified by differential analysis and intersected with GM. Multiple machine learning algorithms were applied to screen and verify the diagnostic genes of intersection genes. In addition, we constructed diagnostic models and nomogram models based on diagnostic genes. The immune landscape of MG was explored by ssGSEA analysis. The correlation between the abundance of immune cell infiltration and diagnostic genes was explored by immune infiltration analysis. Finally, the diagnostic genes were further validated by qPCR experiments.

PMID:39937929 | DOI:10.1080/08916934.2025.2465410


Source: https://pubmed.ncbi.nlm.nih.gov/3993792 ... t9+e462414