[Pubmed] Climate Change Associated with Declining Clinical Outcomes in Myasthenia Gravis for US States with the Greatest

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Neurology. 2024 Apr 9;102(7_supplement_1):6313. doi: 10.1212/WNL.0000000000206388. Epub 2024 Apr 9.

ABSTRACT

OBJECTIVE: To investigate the effect of climate change and global warming on myasthenia gravis (MG) mortality and exacerbation in US states with the greatest and least increase in temperature.

BACKGROUND: The effect of temperature changes on neuromuscular junction transmission in MG is well known. The effect of global warming inducing ambient temperature increase over time is less understood.

DESIGN/METHODS: A retrospective analysis was conducted from EPIC Electronic Medical Record System data. 5,538 MG patients were identified from 2007-2009 (P1 period) and 85,008 MG patients from 2020-2022 (P2 period). The 5 states (SHT: Alaska, Florida, West Virginia, Ohio, Pennsylvania) with the greatest temperature increase and 5 states (SLT: Oklahoma, North Dakota, Missouri, Kansas, Arkansas) with the lowest temperature increase between P1 and P2 were identified from the National Centers for Environmental Information database.

RESULTS: P2 patients had a higher mortality rate (P2/P1: 6.5%±0.16% vs 1.7%±0.33%; p

Source: https://pubmed.ncbi.nlm.nih.gov/3997789 ... t9+e462414