[Pubmed] A case of irAE myositis with positive anti-striational antibodies after anti-PD-L1 antibody administration: a c

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Mod Rheumatol Case Rep. 2025 May 30:rxaf025. doi: 10.1093/mrcr/rxaf025. Online ahead of print.

ABSTRACT

Immune checkpoint inhibitors (ICIs) are widely used in clinical practice, necessitating appropriate management of immune-related adverse events (irAEs). Although severe neurologic irAEs are less common, they often lead to poor outcomes, requiring early detection and prompt intervention. An 88-year-old woman with invasive urothelial carcinoma received 6 cycles of gemcitabine plus carboplatin followed by avelumab, an anti-PD-L1 antibody, as maintenance therapy. One week later, she developed progressive limb weakness and was diagnosed with irAE myositis based on elevated CK levels and imaging findings. Early treatment with methylprednisolone pulse therapy, followed by prednisolone (1 mg/kg BW), led to rapid improvement, and no relapse occurred after PSL completion at four months. irAE myositis has clinical, pathological and immunological features that differ from known inflammatory muscle diseases. In this case, the time to onset and the presence of anti-striational antibodies were consistent with previous reports focusing on anti-PD-1 antibodies, whereas ocular symptoms, myocarditis, and myasthenia gravis, which are considered characteristic of irAE myositis, were not observed. Given the expected increase in high-grade neurological irAEs, accumulating case reports is essential to better understand the differences in clinical presentation and prognosis, which may vary depending on drug-specific effects and autoantibody profiles. Furthermore, this case suggests that some patients with irAE myositis may successfully taper or discontinue prednisolone earlier than traditionally expected.

PMID:40445182 | DOI:10.1093/mrcr/rxaf025


Source: https://pubmed.ncbi.nlm.nih.gov/4044518 ... t9+e462414