[SMLE] Fluctuating, but Not Forgotten: Recognizing Neuromuscular Junction Disorders

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Emerg Med Clin North Am. 2026 May;44(2):399-411. doi: 10.1016/j.emc.2025.11.004. Epub 2026 Jan 8.

ABSTRACT

The neuromuscular junction (NMJ), the connection between nerve and muscle, is an essential anatomic site that warrants careful consideration. Dysfunction at this junction often leads to skeletal muscle weakness with a multitude of clinical manifestations. Disorders of the NMJ primarily encompass myasthenia gravis, Lambert-Eaton syndrome, botulism, and organophosphate poisoning. This article will review diseases and disorders of the NMJ, their clinical presentations, and approach to management.

PMID:41895886 | DOI:10.1016/j.emc.2025.11.004


Source: https://pubmed.ncbi.nlm.nih.gov/4189588 ... t6+133c1fe