[Pubmed] Neuro-Ophthalmic Complications of Immune Checkpoint Inhibitors

[RSS-Bot]

Neurol Clin. 2026 May;44(2):279-290. doi: 10.1016/j.ncl.2025.11.005. Epub 2026 Jan 27.

ABSTRACT

Neuro-ophthalmic complications associated with immune checkpoint inhibitors (ICIs) are rare. These involve adverse events primarily affecting the optic nerve, other cranial nerves, and the neuromuscular junction. Myasthenia gravis-like syndrome (often with concomitant myositis) is the most commonly reported immune-related adverse event, followed by optic neuropathy, of which the most notable is optic neuritis. Symptoms typically present within 6 months of exposure. Prompt and comprehensive evaluation is essential. Diagnostic work-up may include MRI brain and orbits, lumbar puncture, serum, and cerebrospinal fluid antibody testing.

PMID:41922037 | DOI:10.1016/j.ncl.2025.11.005


Source: https://pubmed.ncbi.nlm.nih.gov/4192203 ... t6+133c1fe